p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli.

@article{Kang2001p38MA,
  title={p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli.},
  author={S W Kang and Sharon G. Adler and Janine Lapage and Rama Natarajan},
  journal={Kidney international},
  year={2001},
  volume={60 2},
  pages={543-52}
}
BACKGROUND The p38 mitogen-activated protein kinase (MAPK) pathway is activated by several stress factors, potentially leading to cellular apoptosis and growth. Little is known about the pattern of glomerular p38 MAPK pathway activation during the course of diabetic nephropathy (DN). We examined the activity and expression of the p38 MAPK pathway members, p38 MAPK, MKK3/6, cAMP-responsive element binding protein (CREB), and MAPK phosphatase-1 (MKP-1), in experimental DN in rats over the course… CONTINUE READING