p38 MAPK activation triggers pharmacologically-induced beta-adrenergic preconditioning, but not ischaemic preconditioning.

@article{Marais2001p38MA,
  title={p38 MAPK activation triggers pharmacologically-induced beta-adrenergic preconditioning, but not ischaemic preconditioning.},
  author={Erna Marais and Sonia Genade and Hans Strijdom and J A Moolman and Amanda Lochner},
  journal={Journal of molecular and cellular cardiology},
  year={2001},
  volume={33 12},
  pages={2157-77}
}
p38 Mitogen-activated protein kinase (p38 MAPK) is activated by short episodes of ischaemia-reperfusion as well as by sustained ischemia followed by reperfusion, Whether activation of this kinase is beneficial or deleterious to the ischaemic heart is still a subject of controversy. Since transient beta-adrenergic stimulation (5 min) stimulates p38 MAPK activation and mimics the cardioprotection of ischaemic preconditioning, it was used as a tool to further evaluate the role of this kinase in… CONTINUE READING

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