p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells.

@article{Pisegna2004p38MA,
  title={p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells.},
  author={Simona Pisegna and Gianluca Pirozzi and M Beretta Piccoli and Luigi Frati and Angela Santoni and Gabriella Palmieri},
  journal={Blood},
  year={2004},
  volume={104 13},
  pages={4157-64}
}
Natural killer (NK) cells are a component of the innate immunity against viral infections through their rapid cytotoxic activity and cytokine production. Although the synthetic double-stranded (ds) RNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, is known to rapidly up-regulate their in vivo functions, NK cell ability to directly respond to dsRNA is still mostly unknown. Our results show that treatment with poly I:C significantly up-regulates both… CONTINUE READING