p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

@article{Kumar2003p38MK,
  title={p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases},
  author={S. Madhava Kumar and Jeffrey C Boehm and John Cho Lee},
  journal={Nature Reviews Drug Discovery},
  year={2003},
  volume={2},
  pages={717-726}
}
The p38 MAP kinases are a family of serine/threonine protein kinases that play important roles in cellular responses to external stress signals. Since their identification about 10 years ago, much has been learned of the activation and regulation of the p38 MAP kinase pathways. Inhibitors of two members of the p38 family have been shown to have anti-inflammatory effects in preclinical disease models, primarily through the inhibition of the expression of inflammatory mediators. Several promising… CONTINUE READING
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