p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.

@article{Zwang2006p38MK,
  title={p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.},
  author={Yaara Zwang and Yosef Yarden},
  journal={The EMBO journal},
  year={2006},
  volume={25 18},
  pages={4195-206}
}
The epidermal growth factor receptor (EGFR) frequently associates with cancer and already serves as a target for therapy. We report that inflammatory cytokines and ultraviolet (UV) irradiation respectively induce transient or sustained phosphorylation of EGFR. Subsequently, EGFR internalizes via a Clathrin-mediated process. In cytokine-stimulated cells, EGFR recycles back to the cell surface, whereas in irradiated cells it arrests in Rab5-containing endosomes. Under both conditions, receptor… CONTINUE READING
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