p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures.

@article{Jeohn2002p38MK,
  title={p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures.},
  author={G H Jeohn and Cynthia Lynn Cooper and B. B. Cokhale Wilson and Raymond Chuen-Chung Chang and Kyung-Jin Jang and Hyoung-Chun Kim and Bing Liu and Jau-Shyong Hong},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={962},
  pages={
          332-46
        }
}
Immune stimulants, such as the bacterial endotoxin, lipopolysaccharide (LPS), the human immunodeficiency virus-1 coat protein gp120, or beta-amyloid peptides, lead to glial activation and production of various immune mediators, such as nitric oxide (NO) and proinflammatory cytokines in the brain. These mediators appear to contribute to neuronal cell death in neurodegenerative diseases. However, the signaling pathways, which mediate the neurotoxic effect by the endotoxin, are not understood. The… CONTINUE READING
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