p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

@article{Menon2010p38MK,
  title={p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.},
  author={Manoj B Menon and Jessica Schwermann and Anurag K. Singh and Mirita Franz-Wachtel and Oliver Pabst and Ursula Seidler and M. Bishr Omary and Alexey Kotlyarov and Matthias Gaestel},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 43},
  pages={33242-51}
}
The MAPK-activated protein kinases (MAPKAP kinases) MK2 and MK3 are directly activated via p38 MAPK phosphorylation, stabilize p38 by complex formation, and contribute to the stress response. The list of substrates of MK2/3 is increasing steadily. We applied a phosphoproteomics approach to compare protein phosphorylation in MK2/3-deficient cells rescued or not by ectopic expression of MK2. In addition to differences in phosphorylation of the known substrates of MK2, HSPB1 and Bag-2, we… CONTINUE READING
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