p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment.

  title={p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment.},
  author={Simona Saccani and Serafino Pantano and Gioacchino Natoli},
  journal={Nature immunology},
  volume={3 1},
We found that inflammatory stimuli induce p38 mitogen-activated protein kinase-dependent phosphorylation and phosphoacetylation of histone H3; this selectively occurred on the promoters of a subset of stimulus-induced cytokine and chemokine genes. p38 activity was required to enhance the accessibility of the cryptic NF-kappa B binding sites contained in H3 phosphorylated promoters, which indicated that p38-dependent H3 phosphorylation may mark promoters for increased NF-kappa B recruitment… CONTINUE READING

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