p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program

  title={p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program},
  author={Mark A. Gillespie and Fabien Le Grand and Anthony Scim{\`e} and Shihuan Kuang and Julia von Maltzahn and Vanessa Seale and Ana Cuenda and Jeffrey A Ranish and Michael Rudnicki},
  booktitle={The Journal of cell biology},
The mitogen-activated protein kinase p38-gamma is highly expressed in skeletal muscle and is associated with the dystrophin glycoprotein complex; however, its function remains unclear. After induced damage, muscle in mice lacking p38-gamma generated significantly fewer myofibers than wild-type muscle. Notably, p38-gamma-deficient muscle contained 50% fewer satellite cells that exhibited premature Myogenin expression and markedly reduced proliferation. We determined that p38-gamma directly… CONTINUE READING

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