p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.

@article{Lawson2013p38MP,
  title={p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.},
  author={Sarah K Lawson and Elena Dobrikova and Mayya Shveygert and Matthias Gromeier},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 1},
  pages={127-35}
}
The p38α to p38δ mitogen-activated protein kinases (MAPKs) are central regulatory nodes coordinating acute stress and inflammatory responses. Their activation leads to rapid adjustment of protein synthesis, for instance translational induction of proinflammatory cytokines. The only known direct link of p38 to translation machinery is the MAPK signal-integrating kinase Mnk. Only p38α and p38β transcripts are ubiquitously expressed. These mRNAs encode highly conserved proteins that equally… CONTINUE READING

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