p38α MAPK mediates 17β-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells.

Abstract

Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol (E(2)) treatment is sufficient to inhibit cell proliferation and cell migration in human colon cancer cells. Up-regulation of urokinase plasminogen activator (uPA), tissue plasminogen… (More)
DOI: 10.1002/jcp.24072

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@article{Hsu2012p38MM, title={p38α MAPK mediates 17β-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells.}, author={Hsi-Hsien Hsu and Chung-Jung Liu and Chia-Yao Shen and Yi-Jyun Chen and Li-mien Chen and W. G. Kuo and Yueh-min Lin and Ray-Jade Chen and Chang-Hai Tsai and Fuu-Jen Tsai and Chih-Yang Huang}, journal={Journal of cellular physiology}, year={2012}, volume={227 11}, pages={3648-60} }