p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.

@article{Town2002p35Cdk5PM,
  title={p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.},
  author={Terrence C. Town and Joseph Zolton and Reed Shaffner and Billy Schnell and Robert M Crescentini and Yajuan Wu and Jin Zeng and Anthony Delledonne and Demian F. Obregon and Jun Tan and Mike Mullan},
  journal={Journal of neuroscience research},
  year={2002},
  volume={69 3},
  pages={362-72}
}
Alzheimer's disease (AD) is pathologically characterized by deposition of amyloid-beta peptides (Abeta) as senile plaques and by the occurrence of neurofibrillary tangles (NFTs) composed primarily of hyperphosphorylated tau protein. Activation of cyclin-dependent kinase 5 (Cdk5) via its potent activator p25 has recently been shown to promote phosphorylation of tau at AD-specific phosphoepitopes, and increased cleavage of p35 to p25 has been demonstrated in AD patients, suggesting that Cdk5 may… CONTINUE READING
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