p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment

@inproceedings{Hagan2011p31cometAT,
  title={p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment},
  author={Robert S. Hagan and Michael S. Manak and H{\aa}kon Kirkeby Buch and Michelle G. Meier and Patrick Meraldi and Jagesh V. Shah and Peter K. Sorger and Stephen John Doxsey},
  booktitle={Molecular biology of the cell},
  year={2011}
}
The spindle assembly checkpoint links the onset of anaphase to completion of chromosome-microtubule attachment and is mediated by the binding of Mad and Bub proteins to kinetochores of unattached or maloriented chromosomes. Mad2 and BubR1 traffic between kinetochores and the cytosol, thereby transmitting a "wait anaphase" signal to the anaphase-promoting complex. It is generally assumed that this signal dissipates automatically upon kinetochore-microtubule binding, but it has been shown that… CONTINUE READING
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