p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc

@article{Sankar2008p300PA,
  title={p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc},
  author={Natesan Sankar and Sudhakar Baluchamy and R-K Kadeppagari and Garima Singhal and Sigmund Weitzman and Bayar Thimmapaya},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={5717-5728}
}
We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit. Here, we have studied the mechanism by which p300 represses c-Myc and show that in quiescent cells p300 cooperates with histone deacetylase 3 (HDAC3) to repress transcription. p300 and HDAC3 are recruited to the upstream YY1-binding site of the c-Myc promoter resulting in chromatin deacetylation and repression of c-Myc transcription. Consistent with… CONTINUE READING