p300/CBP histone acetyltransferase activity is required for newly acquired and reactivated fear memories in the lateral amygdala.

@article{Maddox2013p300CBPHA,
  title={p300/CBP histone acetyltransferase activity is required for newly acquired and reactivated fear memories in the lateral amygdala.},
  author={Stephanie A. Maddox and Casey S. Watts and Glenn E. Schafe},
  journal={Learning & memory},
  year={2013},
  volume={20 2},
  pages={109-19}
}
Modifications in chromatin structure have been widely implicated in memory and cognition, most notably using hippocampal-dependent memory paradigms including object recognition, spatial memory, and contextual fear memory. Relatively little is known, however, about the role of chromatin-modifying enzymes in amygdala-dependent memory formation. Here, we use a combination of biochemical, behavioral, and neurophysiological methods to systematically examine the role of p300/CBP histone… CONTINUE READING
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Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability

  • LM Valor, MM Pulopulos, M Jimenez-Minchan, R Olivares, B Lutz, A. Barco
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