p300/CBP/p53 interaction and regulation of the p53 response.

  title={p300/CBP/p53 interaction and regulation of the p53 response.},
  author={Steven R. Grossman},
  journal={European journal of biochemistry},
  volume={268 10},
Substantial evidence points to a critical role for the p300/CREB binding protein (CBP) coactivators in p53 responses to DNA damage. p300/CBP and the associated protein P/CAF bind to and acetylate p53 during the DNA damage response, and are needed for full p53 transactivation as well as downstream p53 effects of growth arrest and/or apoptosis. Beyond this simplistic model, p300/CBP appear to be complex integrators of signals that regulate p53, and biochemically, the multipartite p53/p300/CBP… CONTINUE READING

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