p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

@article{Boussiotis2000p27kip1FA,
  title={p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes},
  author={Vassiliki A Boussiotis and Gordon J Freeman and Patricia A. Taylor and Alla Berezovskaya and Isabelle Grass and Bruce R Blazar and Lee M. Nadler},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={290-297}
}
Although recent in vitro studies have begun to decipher the molecular events that characterize the anergic state, their in vivo biologic relevance and potential clinical importance remain unclear. Here, using anergic human T-cell clones and tolerant alloreactive mouse T cells that do not induce graft-versus-host disease, we show that p27kip1 cyclin-dependent kinase inhibitor is an essential regulator responsible for the blockade of clonal expansion of anergic T cells in vitro and in vivo… CONTINUE READING

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