p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers.

@article{Lloyd1999p27kip1AM,
  title={p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers.},
  author={Ricardo Vincent Lloyd and Lori A Erickson and Long Jin and Elzbieta Kulig and Xiang zhong Qian and John C. Cheville and Bernd Walter Scheithauer},
  journal={The American journal of pathology},
  year={1999},
  volume={154 2},
  pages={313-23}
}
p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family. p27 expression is regulated by cell contact inhibition and by specific growth factors, such as transforming growth factor (TGF)-beta. Since the cloning of the p27 gene in 1994, a host of other functions have been associated with this cell cycle protein. In addition to its role as a CDKI, p27 is a putative tumor suppressor gene, regulator of drug resistance in solid tumors, and promoter of apoptosis; acts… CONTINUE READING

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