p27Kip1-stathmin interaction influences sarcoma cell migration and invasion

@inproceedings{Baldassarre2005p27Kip1stathminII,
  title={p27Kip1-stathmin interaction influences sarcoma cell migration and invasion},
  author={Gustavo Baldassarre and Barbara Belletti and Milena Sabrina Nicoloso and Monica Schiappacassi and Andrea Vecchione and Paola Spessotto and Andrea Morrione and Vincenzo Canzonieri and Alfonso Colombatti},
  year={2005}
}
Abstract Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27 kip1 affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents. This p27 kip1 activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27… CONTINUE READING

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