p27Kip1 metabolism: a fascinating labyrinth.

  title={p27Kip1 metabolism: a fascinating labyrinth.},
  author={Adriana Borriello and Valeria Cucciolla and Adriana Oliva and Vincenzo Zappia and Fulvio della Ragione},
  journal={Cell cycle},
  volume={6 9},
The progression through the phases of cell division cycle is regulated by different cyclins and cyclin-dependent kinases (CDKs) complexes. Due to their key function, the activity of cyclin/CDK complexes is controlled by several mechanisms, including the inhibition by a number of proteins collectively defined CDK inhibitors or CKIs. Among the CKIs, p27Kip1 represents a protein of central activity for the control of several phenotypes, including proliferation, differentiation and malignant… CONTINUE READING


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