p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells

@article{Eymin1999p27Kip1ID,
  title={p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells},
  author={B{\'e}atrice Eymin and Monika Haugg and Nathalie Droin and Olivier Sordet and Marie-Th{\'e}r{\^e}se Dimanche-Boitrel and {\'E}ric Solary},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1411-1418}
}
The cyclin-dependent kinase inhibitor p27Kip1 has been implicated as a drug resistance factor in tumor cells grown as spheroids or confluent monolayers. Here, we show that p27Kip1 overexpression also induces resistance to drug-induced apoptosis and cytotoxicity in human leukemic cells growing in suspension. The anti-apoptotic effect of p27Kip1 is not restricted to DNA-damaging agents but extends to the tubulin poison vinblastin, agonistic anti-Fas antibodies and macromolecule synthesis… CONTINUE READING
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