p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation

@article{Durand1998p27Kip1AT,
  title={p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation},
  author={B{\'e}atrice Durand and Matthew L. Fero and James M Roberts and Martin C. Raff},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={431-440}
}
BACKGROUND In many vertebrate cell lineages, precursor cells divide a limited number of times before they arrest and terminally differentiate into postmitotic cells. It is not known what causes them to stop dividing. We have been studying the 'stopping' mechanism in the proliferating precursor cells that give rise to oligodendrocytes, the cells that make myelin in the central nervous system. We showed previously that the cyclin-dependent kinase inhibitor p27Kip1 (p27) progressively accumulates… CONTINUE READING