p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression.

  title={p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression.},
  author={Karin Zerfass-Thome and Almut Schulze and Werner Zwerschke and B Vogt and Kristian Helin and Jiri Bartek and Berthold Henglein and Pidder Jansen-Duerr},
  journal={Molecular and cellular biology},
  volume={17 1},
Cyclin E is necessary and rate limiting for the passage of mammalian cells through the G1 phase of the cell cycle. Control of cell cycle progression by cyclin E involves cdk2 kinase, which requires cyclin E for catalytic activity. Expression of cyclin E/cdk2 leads to an activation of cyclin A gene expression, as monitored by reporter gene constructs derived from the human cyclin A promoter. Promoter activation by cyclin E/cdk2 requires an E2F binding site in the cyclin A promoter. We show here… CONTINUE READING

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