p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs.

@article{Belletti2005p27kip1FR,
  title={p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs.},
  author={Barbara Belletti and Milena Sabrina Nicoloso and Monica Schiappacassi and Emanuela Chimienti and Stefania Berton and Francesca Lovat and Alfonso Colombatti and Gustavo Baldassarre},
  journal={Current medicinal chemistry},
  year={2005},
  volume={12 14},
  pages={
          1589-605
        }
}
The mitotic cell cycle is a tightly regulated process that ensures the correct division of one cell into two daughter cells. Progress along the different phases of the cell cycle is positively regulated by the sequential activation of a family of serine-threonine kinases called CDKs (Cyclin Dependent Kinases). Their activity is counteracted by small proteins known as CDK inhibitors (CKI) that ensure the correct timing of CDK activation in the different phases of the cell cycle. The present… CONTINUE READING
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