p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma.

@article{Fornaro1999p27kip1AA,
  title={p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma.},
  author={Mara Fornaro and Giovanni Tallini and D Q Zheng and William Michael Flanagan and Michela Manzotti and Lucia R. Languino},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 3},
  pages={
          321-9
        }
}
Integrins are a large family of transmembrane receptors that, in addition to mediating cell adhesion, modulate cell proliferation. The beta1C integrin is an alternatively spliced variant of the beta1 subfamily that contains a unique 48-amino acid sequence in its cytoplasmic domain. We have shown previously that in vitro beta1C inhibits cell proliferation and that in vivo beta1C is expressed in nonproliferative, differentiated epithelium and is selectively downregulated in prostatic… CONTINUE READING

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Integrins and Prostate Cancer Metastases

  • Cancer and Metastasis Reviews
  • 2001
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