p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

@article{Cruz2006p25cyclindependentK5,
  title={p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.},
  author={Jonathan Cruz and Dohoon Kim and Lily Y. Moy and Matthew M. Dobbin and Xiaoyan Sun and Roderick Terry Bronson and Li-Huei Tsai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 41},
  pages={10536-41}
}
Aberrant processing of the amyloid precursor protein (APP) and the subsequent accumulation of amyloid beta (Abeta) peptide has been widely established as a central event in Alzheimer's disease (AD) pathogenesis. The sequential cleavage steps required for the generation of Abeta are well outlined; however, there is a relative dearth of knowledge pertaining to signaling pathways and molecular mechanisms that can modulate this process. Here, we demonstrate a novel role for p25/cyclin-dependent… CONTINUE READING
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