p21Waf1/Cip1 Expression Is a Prognostic Marker in Curatively Resected Esophageal Squamous Cell Carcinoma, but Not p27Kip1, p53, or Rb

@article{Nita1999p21Waf1Cip1EI,
  title={p21Waf1/Cip1 Expression Is a Prognostic Marker in Curatively Resected Esophageal Squamous Cell Carcinoma, but Not p27Kip1, p53, or Rb},
  author={Marcelo Eidi Nita and Hirokazu Nagawa and Osamu Tominaga and Nelson Hirokazu Tsuno and Kenji Hatano and Joji Kitayama and Takashi Tsuruo and Carlos Eduardo Domene and Tetsuichiro Muto},
  journal={Annals of Surgical Oncology},
  year={1999},
  volume={6},
  pages={481-488}
}
Background: p21Waf1/Cip1 (p21), p27Kip1 (p27), p53, and Rb play critical roles in cell cycle regulation and may influence the clinical behavior of tumors. We examined whether their expression is useful to predict survival of patients with esophageal squamous cell carcinoma (ESC). Methods: Expression of p21, p27, p53, and Rb was studied by the immunohistochemical method in specimens from 62 patients with curatively resected ESC tumors and scored by a computerized image analysis system. Results… CONTINUE READING

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