p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression.

@article{Mueller2000p21WAF1RA,
  title={p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression.},
  author={Susanne Mueller and Enrique Cadenas and Axel H Sch{\"o}nthal},
  journal={Cancer research},
  year={2000},
  volume={60 1},
  pages={
          156-63
        }
}
The cyclin-dependent kinase inhibitor p21WAF1 has been characterized as an important effector of the tumor suppressor p53 and has been linked to various growth-regulatory processes. To identify a potential role of p21 in anchorage-dependent growth control, we analyzed a pair of HCT116 human colon carcinoma cell lines that differed only in their p21 status. We found that during suspension culture, HCT116 cells (which contain wildtype p53 and p21) continued to proliferate and formed compact… CONTINUE READING

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