p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium.

  title={p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium.},
  author={Mario Gennaro Cozzolino and Yan Lu and Jane Finch and Eduardo A. Slatopolsky and Adriana S. Dusso},
  journal={Kidney international},
  volume={60 6},
BACKGROUND High dietary phosphorus (P) worsens uremia-induced parathyroid (PT) hyperplasia through increases in the growth promoter transforming growth factor-alpha (TGF-alpha). In contrast, P restriction prevents PT hyperplasia by inducing the cell cycle inhibitor p21. Since 1,25(OH)2D3-antiproliferative action in various cell types involve increases in p21, we studied whether induction of p21 by 1,25(OH)2D3 or the vitamin D analog, 19-Nor-1,25(OH)2D2, could counteract the PT hyperplasia… CONTINUE READING


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