p21WAF1/CIP1 expression in non-melanoma skin tumors.

  title={p21WAF1/CIP1 expression in non-melanoma skin tumors.},
  author={N. U. Ahmed and Masato Ueda and Masamitsu Ichihashi},
  journal={Journal of cutaneous pathology},
  volume={24 4},
Abnormal control of the cell cycle is closely linked to carcinogenesis. p21WAF1/CIP1 protein is a universal inhibitor of G1 cyclin-dependent kinase and is induced by p53-dependent and -independent pathways. In order to elucidate the role of p21WAF1/CIP1 in human skin carcinogenesis, protein expression in squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Bowen's disease (BD), actinic keratosis (AK), keratoacanthoma (KA), seborrheic keratosis (SK), and normal skin was examined using an… CONTINUE READING