p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells.

@article{MuozAlonso2005p21Cip1AP,
  title={p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells.},
  author={Mar{\'i}a Jos{\'e} Mu{\~n}oz-Alonso and Juan Carlos Acosta and Carlos Richard and Maria Dolores Delgado and John Sedivy and Javier Zalamea Le{\'o}n},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 18},
  pages={18120-9}
}
The cyclin-dependent kinase (Cdk) inhibitors p21(Cip1) and p27(Kip1) have been proposed to exert redundant functions in cell cycle progression and differentiation programs, although nonoverlapping functions have also been described. To gain further insights into the relevant mechanisms and to detect possible functional differences between both proteins, we conditionally expressed p21(Cip1) and p27(Kip1) in K562, a multipotent human leukemia cell line. Temporal ectopic expression of either p21… CONTINUE READING

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