p21B, a variant of p21Waf1/Cip1, is induced by the p53 family

@article{Nozell2002p21BAV,
  title={p21B, a variant of p21Waf1/Cip1, is induced by the p53 family},
  author={Susan E Nozell and Xinbin Chen},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={1285-1294}
}
Alternative splicing or expression from an alternate promoter can produce variants of a gene. To determine whether the p21Waf1/Cip1 locus is regulated by these mechanisms, we searched for and found two transcripts, p21B and p21C, that are expressed from an alternate promoter in the first intron of the p21 gene. While p21C encodes the p21 cyclin-dependent kinase inhibitor, p21B encodes a novel protein and the transcript is ubiquitously expressed in 16 human tissues tested. Like p21, both p21B… CONTINUE READING
BETA

Similar Papers

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Effects of Iejimalide B, a marine macrolide, on growth and apoptosis in prostate cancer cell lines.

  • Journal of cellular biochemistry
  • 2008
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED