p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

@inproceedings{Yosef2017p21MS,
  title={p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling},
  author={Reut Yosef and Noam Pilpel and Nurit Papismadov and Hilah Gal and Yossi Ovadya and Ezra Vadai and Stav Miller and Ziv Porat and Shifra Ben-Dor and Valery Krizhanovsky},
  booktitle={The EMBO journal},
  year={2017}
}
Cellular senescence is a permanent state of cell cycle arrest that protects the organism from tumorigenesis and regulates tissue integrity upon damage and during tissue remodeling. However, accumulation of senescent cells in tissues during aging contributes to age-related pathologies. A deeper understanding of the mechanisms regulating the viability of senescent cells is therefore required. Here, we show that the CDK inhibitor p21 (CDKN1A) maintains the viability of DNA damage-induced senescent… CONTINUE READING
Tweets
This paper has been referenced on Twitter 15 times. VIEW TWEETS