p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels

@article{Park2007p21ID,
  title={p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels},
  author={Jinyoung Park and William E. Schutzer and Jessie N Lindsley and Susan P. Bagby and Terry T Oyama and Sharon Anderson and Robert H. Weiss},
  journal={BMC Nephrology},
  year={2007},
  volume={8},
  pages={12 - 12}
}
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts to suppress cell cycle progression and to prevent apoptosis. Because defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in PKD, and in light of earlier reports that polycystin-1 upregulates p21 and that the… CONTINUE READING
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