p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.

@article{Roy2007p21AP,
  title={p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.},
  author={Srirupa Roy and Manjinder Kaur and Chapla Agarwal and Marianne Tecklenburg and Robert A Sclafani and Rajesh Agarwal},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 10},
  pages={
          2696-707
        }
}
Recent studies have shown that silibinin induces p21/Cip1 and p27/Kip1 and G1 arrest in different prostate cancer cells irrespective of p53 status; however, biological significance and mechanism of such induction have not been studied. Here, using two different prostate cancer cell lines DU145 and 22Rv1, representing androgen-independent and androgen-dependent stages of malignancy, first we investigated the importance of p21 and p27 induction in silibinin-mediated G1 arrest. Silencing p21 and… CONTINUE READING

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