p21-activated kinases in cancer

@article{Kumar2006p21activatedKI,
  title={p21-activated kinases in cancer},
  author={Rakesh Kumar and Anupama E. Gururaj and Christopher J. Barnes},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={459-471}
}
The pivotal role of kinases in signal transduction and cellular regulation has lent them considerable appeal as pharmacological targets across a broad spectrum of cancers. p21-activated kinases (Paks) are serine/threonine kinases that function as downstream nodes for various oncogenic signalling pathways. Paks are well-known regulators of cytoskeletal remodelling and cell motility, but have recently also been shown to promote cell proliferation, regulate apoptosis and accelerate mitotic… 

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It is concluded that aberrant mitogenic signaling in human breast cancer in vivo involves Pak, p38 MAPK and MAPKAPK2 downstream of PI3‐K, but neither of PKB or p70 S6K, and it is proposed that this pathway may serve as a useful targeting nexus for investigation of small molecule inhibitors inhuman breast cancer.

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The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis*

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p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

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