p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Abstract

Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcepsilonRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE activation to calcium influx and cytoskeletal changes required for intracellular granule release are incompletely understood. We demonstrate, genetically… (More)
DOI: 10.1182/blood-2008-06-160861

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Cite this paper

@article{Allen2009p21activatedKR, title={p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.}, author={Jayme D Allen and Zahara M. Jaffer and Su-Jung Park and Sarah J M Burgin and Clemens Hofmann and Mary Ann Sells and Shi Chen and Ethel C Derr-Yellin and Elizabeth G Michels and Andrew McDaniel and Waylan K Bessler and D. Ingram and Simon Atkinson and Jeffrey Bryant Travers and Jonathan Chernoff and D. Wade Clapp}, journal={Blood}, year={2009}, volume={113 12}, pages={2695-705} }