p21-activated kinase links Rac/Cdc42 signaling to merlin.

  title={p21-activated kinase links Rac/Cdc42 signaling to merlin.},
  author={G H Xiao and Alexander Beeser and Jonathan Chernoff and Joseph R Testa},
  journal={The Journal of biological chemistry},
  volume={277 2},
The neurofibromatosis type 2 tumor suppressor gene, NF2, is mutated in the germ line of NF2 patients and predisposes affected individuals to intracranial and spinal tumors. Moreover, somatic mutations of NF2 can occur in the sporadic counterparts of these neurological tumor types as well as in certain neoplasms of non-neuroectodermal origin, such as malignant mesothelioma and melanoma. NF2 encodes a 595-amino acid protein, merlin, which exhibits significant homology to the ezrin-radixin-moesin… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 113 extracted citations

Similar Papers

Loading similar papers…