p21-activated kinase PAK phosphorylates desmin at sites different from those for Rho-associated kinase.

@article{Ohtakara2000p21activatedKP,
  title={p21-activated kinase PAK phosphorylates desmin at sites different from those for Rho-associated kinase.},
  author={Kazuhiro Ohtakara and Hiroyasu Inada and Hiroaki Goto and Waro Taki and Ed Manser and Louis Lim and Ichiro Izawa and Masaki Inagaki},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={272 3},
  pages={
          712-6
        }
}
p21-activated kinase (PAK) and Rho-associated kinase (Rho-kinase) have been shown to induce Ca(2+)-independent contraction of smooth muscle. PAK-induced contraction of Triton-skinned smooth muscle correlates with increased phosphorylation of caldesmon and desmin, although the role of desmin phosphorylation has remained obscure. Here we report that desmin serves as an excellent substrate for PAK in vitro. PAK phosphorylated desmin in a GTP. Cdc42/Rac-dependent manner. Phosphorylation of desmin… CONTINUE READING

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