p21-Activated kinase 4 promotes prostate cancer progression through CREB

@article{Park2013p21ActivatedK4,
  title={p21-Activated kinase 4 promotes prostate cancer progression through CREB},
  author={M Park and H J Lee and C-S Lee and Soon Tae You and D Kim and B-H Park and Min Ji Kang and Won Heo and E-Y Shin and Martin A Schwartz and E Kim},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={2475-2482}
}
Prostate cancer is initially androgen-dependent but, over time, usually develops hormone- and chemo-resistance. The present study investigated a role for p21-activated kinase 4 (PAK4) in prostate cancer progression. PAK4 activation was markedly inhibited by H89, a specific protein kinase A (PKA) inhibitor, and PAK4 was activated by the elevation of cAMP… CONTINUE READING