p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.

  title={p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.},
  author={Katherine A. Sheehan and Yunbo Ke and R. John Solaro},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={293 3},
We review here a novel concept in the regulation of cardiac contractility involving variations in the activity of the multifunctional enzyme, p21-activated kinase 1 (Pak1), a member of a family of proteins in the small G protein-signaling pathway that is activated by Cdc42 and Rac1. There is a large body of evidence from studies in noncardiac tissue that Pak1 activity is key in regulation of a number of cellular functions, including cytoskeletal dynamics, cell motility, growth, and… CONTINUE READING


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