p21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma.

@article{Schmider2000p21P,
  title={p21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma.},
  author={Annette Schmider and Conway Gee and Wolfgang Friedmann and Jeffrey J. Lukas and Michael F Press and Werner Lichtenegger and Angela Reles},
  journal={Gynecologic oncology},
  year={2000},
  volume={77 2},
  pages={237-42}
}
OBJECTIVE The objective of this study was to clarify the influence of p21 protein expression in ovarian cancer. p21 (WAF1 [wild-type p53 activated fragment 1]/CIP1) is a universal cyclin-dependent kinase inhibitor and can be induced as a downstream effector of the p53 tumor suppressor gene. METHODS The expression of p21 was evaluated by immunohistochemical analysis with the monoclonal antibody WAF1 (Oncogene Science) on 106 formalin-fixed, paraffin-embedded tissue samples of epithelial… CONTINUE READING

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