p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer

  title={p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer},
  author={Maarit A. Anttila and V. M. Kosma and J. Hongxiu and Jukka Puolakka and Matti T Juhola and Seppo V. Saarikoski and Kari Juhani Syrj{\"a}nen},
  booktitle={British Journal of Cancer},
SummaryThe role and prognostic value of the tumour suppressor p21/WAF1 expression in epithelial ovarian cancer has not yet been defined. Therefore, the expression of p21/WAF1 was assessed immunohistochemically (IHC) in 316 epithelial ovarian malignancies in relation to p53, cell proliferation and patient survival. p21/WAF1 expression was inversely correlated with p53 and cell proliferation. Low p21/WAF1 expression was significantly associated with high grade of the tumour (P = 0.0005), advanced… CONTINUE READING


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