p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.

@article{Chen2008p19ArfIT,
  title={p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.},
  author={Ya-Wen Chen and Seema Paliwal and Kyle M. Draheim and Steven R. Grossman and Brian C. Lewis},
  journal={Cancer research},
  year={2008},
  volume={68 2},
  pages={
          476-82
        }
}
The INK4A/ARF tumor suppressor locus is frequently inactivated in hepatocellular carcinoma (HCC), yet the consequences of this remain unknown. We recently described a HCC mouse model in which loss of the Ink4a/Arf locus accelerates the development of metastasis and enhances tumor cell migration and invasion in cell culture assays. We show here that knockdown of p19Arf in an HCC cell line increases invasion in cell culture assays. Furthermore, reintroduction of p19(Arf) into HCC cell lines… CONTINUE READING
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