p19ARF directly and differentially controls the functions of c-Myc independently of p53

@article{Qi2004p19ARFDA,
  title={p19ARF directly and differentially controls the functions of c-Myc independently of p53},
  author={Ying Qi and Mark A Gregory and Zhaoliang Li and Jeffrey P. Brousal and Kimberly A West and Stephen R. Hann},
  journal={Nature},
  year={2004},
  volume={431},
  pages={712-717}
}
Increased expression of the oncogenic transcription factor c-Myc causes unregulated cell cycle progression. c-Myc can also cause apoptosis, but it is not known whether the activation and/or repression of c-Myc target genes mediates these diverse functions of c-Myc. Because unchecked cell cycle progression leads to hyperproliferation and tumorigenesis, it is essential for tumour suppressors, such as p53 and p19ARF (ARF), to curb cell cycle progression in response to increased c-Myc (refs 2, 3… CONTINUE READING

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