p185c-erbB-2 signal enhances cisplatin-induced cytotoxicity in human breast carcinoma cells: association between an oncogenic receptor tyrosine kinase and drug-induced DNA repair.

@article{Arteaga1994p185cerbB2SE,
  title={p185c-erbB-2 signal enhances cisplatin-induced cytotoxicity in human breast carcinoma cells: association between an oncogenic receptor tyrosine kinase and drug-induced DNA repair.},
  author={Carlos L. Arteaga and A R Winnier and Miriam C. Poirier and Daniel Mario Lopez-Larraza and Laura K. Shawver and Stephen D. Hurd and Sigrid J Stewart},
  journal={Cancer research},
  year={1994},
  volume={54 14},
  pages={3758-65}
}
The c-erbB-2 (HER-2/neu) protooncogene encodes an M(r) 185,000 transmembrane glycoprotein with intrinsic tyrosine kinase activity. Agonistic antibodies against p185c-erbB-2 enhance the cytotoxic effect of the DNA alkylator, cisplatin, against c-erbB-2-overexpressing human carcinoma cells (Hancock et al., Cancer Res., 51:4575-4580, 1991). We have studied the possible association between receptor signal transduction and cisplatin-mediated cytotoxicity utilizing the SKBR-3 human breast cancer cell… CONTINUE READING

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