p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum

@inproceedings{Cui2012p180PT,
  title={p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum},
  author={Xianying Amy Cui and Hui Zhang and Alexander F. Palazzo},
  booktitle={PLoS biology},
  year={2012}
}
In metazoans, the majority of mRNAs coding for secreted and membrane-bound proteins are translated on the surface of the endoplasmic reticulum (ER). Although the targeting of these transcripts to the surface of the ER can be mediated by the translation of a signal sequence and their maintenance is mediated by interactions between the ribosome and the translocon, it is becoming increasingly clear that additional ER-localization pathways exist. Here we demonstrate that many of these mRNAs can be… CONTINUE READING
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