p16ink4a gene and hematological malignancies.

  title={p16ink4a gene and hematological malignancies.},
  author={Bruno Quesnel and Claude Joseph Preudhomme and Pierre Fenaux},
  journal={Leukemia & lymphoma},
  volume={22 1-2},
Progression of eukaryotic cells through major cell cycle transitions is mediated by sequential assembly and activation of regulators, the cyclin-dependent CDKkinases (CDKs). Recent studies have identified different CDK inhibitory genes (CDKis), and two of them, p16ink4a/MTS1/CDKN2 and p15ink4b/MTS2 are both mapped to chromosome 9p21 and inhibit cyclin D… CONTINUE READING