p16INK4a suppresses BRCA1-deficient mammary tumorigenesis

Abstract

Senescence prevents the proliferation of genomically damaged, but otherwise replication competent cells at risk of neoplastic transformation. p16INK4A (p16), an inhibitor of CDK4 and CDK6, plays a critical role in controlling cellular senescence in multiple organs. Functional inactivation of p16 by gene mutation and promoter methylation is frequently… (More)
DOI: 10.18632/oncotarget.13015

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