p16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy

Abstract

Immunohistochemical assay for p16 protein expession was performed in 192 breast carcinoma patients treated with adjuvant chemotherapy. p16 expression was observed in 78 cases (40.6%). The frequency of p16 expression significantly decreased in moderately differentiated (histologic grade II) cancers, 20 (19.6%) of 102. In poorly differentiated cancers… (More)
DOI: 10.1023/A:1013047413895

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